There were 41 confirmed cases of BSE in the State this year compared to 69 last year, according to the Department of Agriculture.
Two cases of BSE were identified this week.
The figures show there has been a steady decline in BSE cases from 333 in 2002, 182 in 2003 and 126 in 2004.
The Department of Agriculture said the increasing age profile of animals confirmed with the disease indicates that the enhanced controls introduced in 1996 and early 1997 are proving effective.
Over 3.5 million tests have been carried out on dead cattle and on animals intended for human consumption since the department set up an active surveillance programme in 2000.
This includes some 655,000 tests this year up to the end of October.
"The range of controls in place to protect consumers and to eradicate the disease continues to be rigorously enforced.
In particular it should be noted that specified risk material is removed from all cattle slaughtered," the Department of Agriculture said.