GROUP C: Defending champions Real Madrid fielded a weakened side against Genk but a 1-1 draw in Belgium was enough to see them top the group.
Genk trailed to a first-half goal by young Spanish forward Tote, but fought back to clinch a draw when Wesley Sonck headed in from a corner after 86 minutes.
In Rome, Athens scored late to make for a nailbiting finish, but Marco Delvecchio's first-half header put Roma into round two and condemned AEK to UEFA Cup football.
Although Walter Centeno netted a late leveller for AEK, they needed to win in order to go through.
GROUP D: Two goals in two minutes from Argentinian Hernan Crespo helped Inter Milan to a 2-1 win over Ajax Amsterdam and top spot.
Crespo hit the net in the 50th and 52nd minutes after passes from Luigi Di Biagio and Christian Vieri.
Rafael van der Vaart hit the consolation goal for the hosts three minutes into injury time.
Despite the defeat Ajax also made it into the second stage after Rosenborg held Olympique Lyon to a 1-1 draw.
Ajax had a goal disallowed after eight minutes when Rafael van der Vaart's strike was ruled offside.