England suffered a second-half mauling at Loftus Versfeld after their dreams of a shock victory were smashed 55-22 by the ruthless Springboks.
Wing Dan Scarbrough's interception try, converted by skipper Jonny Wilkinson, gave an under-strength England a shock 19-17 interval lead.
But then their world caved in as South Africa cut loose after the break.
Wilkinson finished with 17 points but South Africa contributed eight tries to Bryan Habana (2), Pierre Spies (2), Ricky Januarie, Schalk Burger, Bakkies Botha and Percy Montgomery, who also booted five conversions and a penalty for an 18-point haul, while fly-half Butch James kicked the final conversion.
England's loss came a week after they suffered a record 58-10 defeat in Bloemfontein.