London Irish's native contingent received the ideal tonic for Ireland's Five Nations blues as the in-form Exiles stretched their unbeaten Premiership run to seven matches.
Gloucester continue to suffer on a seemingly terminal bout of travel sickness. In contrast to their impressive home form, they have mustered just one away win all season, and against an Irish side brimming with confidence it was unlikely they would break that awful record.
Both sides exchanged early penalties before Irish stamped their authority on the match.
Their forwards had the better of a hard, physical pack battle, while their increasingly imaginative backs drilled holes in the visitors' defence.
Typically, Niall Woods masterminded their breakthrough score, although it was opportunist Simon Berridge who was on hand to take the glory.
Woods, so inspirational for his club but amazingly still forgotten by his country, continued to be at the centre of all the Exiles' creative endeavour.
A temporary lapse of concentration allowed the visitors to reduce the deficit with a Nathan Carter try, but Irish soon hit back.
In a role reversal of their opener, Berridge battered down Gloucester's defences before releasing Jake Boer, whose perfectly timed pass allowed Woods to grab a deserved try. Stephen Bachop added a drop goal for a comfortable 12-point lead at the break.
The visitors started brightly after the restart but failed to capitalise on their pressure.
While they squandered opportunities, Irish seized every chance. Powerhouse forward Isaac Fea'unati added their third try, and moments later Berridge increased the advantage with his second score.
Irish, now unbeaten for nearly two months, are still not accustomed to their lofty position in the Premiership table and perhaps relaxed too much as Philippe Saint-Andre and Scott Benton ran in consolation scores.
But Jarrod Cunningham showed his pace and Neil Hatley his power as they blazed past the Cherry and Whites to seal yet another haul of maximum points.
Gloucester and England number eight Steve Ojomoh has vowed not to cut his hair until his side win away, and on this evidence the barber may have a long wait.
London Irish coach Dick Best hailed the performance of Woods yesterday and backed him for an immediate recall to the Irish national side. Woods was the power and drive behind yesterday's victory, and his kicking could have been the difference for Ireland in Dublin on Saturday.
"I know he'd love to be playing again. It's his big ambition and he'd take the responsibility of kicking excellently," added Best.
London Irish: Cunningham; Berridge, Todd, Venter, Woods; Bachop, Putt; Hatley, Kirke, Hardwick, Strudwick, Bird, Boer, Gallagher, Feaunati.
Gloucester: Mapletoft; Beim, Fanolua, Tombs, Saint-Andre; Mannix, Benton; Woodman, McCarthy, Powles, Fidler, Sims, Pearce, Carter, Ojomoh.
Referee: T Fisher (Manchester).
