Dublin's digital hub will receive €2.3 million in a joint venture to develop the first phase of enterprise space at the nine-acre site in the Liberties.
Enterprise Ireland, Dublin City Council and Digital Media Development will refurbish the former Guinness Print Depot building in Thomas Street, which will create a broadband-enabled facility with 20,000 square feet of enterprise space for start-up companies and established corporations working in digital media.
The Tánaiste, Ms Harney, said: "Enterprise Ireland has identified the digital media sector as one of the best opportunities for Ireland to develop our high-technology internationally traded services sector."
More than half the space in the new development will be reserved for start-up and early stage companies, with room for up to 20 companies employing up to 180 people between them.
Enterprise Ireland chief executive Mr Dan Flinter said he would work closely with Digital Media Development, which manages the digital hub, to "market the centre to companies involved in film and television, music, animation, design, games and post-production".
More than 50 firms have inquired about locating in the €130 million digital district, according to Mr Paddy Teahon, Digital Media Development chairman.