Across:
1 Once you have it, you’ll never lose it (never ‘lose it’ when you have PATIENCE OF JOB), as those interested in The Cure (‘patients’ = ‘PATIENCE’) on the radio (= homophone indicator) love (O-) loud music (forte = -F) at Project (JOB) (PATIENCE OF JOB),
10 Counter (AGAINST) with ale from East Anglia (‘ale’ from ‘East Anglia’ = stangi = AGAINST),
11 Couple (2) of thousand (grand + M) (GRANDM-) at academy (-A) (GRANDMA) parodied by one of those in a pack? (GRANDMA parodied by one of those in a pack/ wolf in Little Red Riding Hood),
12 Omen from newcomer (‘omen’ from ‘newcomer’ = ewcr = CREW) pulling the strokes (CREW),
13 Restore (RENEW) Carry on Again? (RENEW),
15 Birdhouse from Outer Hebrides (‘birdhouse’ from ‘Outer Hebrides’ = tere = TREE) is a perfect place for a nest (TREE),
17 It’s empty talk (GAS) sending up (= reversal indicator) actor’s agent in part (‘actorS AGent’ in part = sag = GAS),
19 For Christmas (TURKEY) with heartless (remove centre = n) old jailer (‘turnkey’ without ‘n’ = TURKEY),
21 Direct (direct = CREDIT) Rocky (= anagram indicator) with cash advance (CREDIT),
22 One of those in local (REGULAR in local/public house) is similar to 34 across (similar to ‘uniform’ = REGULAR),
23 All backed (= reverse all indicator) leader’s generous attention (leaders ‘Generous Attention’ = ga = -AG-) welcomed by The House (semi = IM-ES) (IMAGES) of Representatives (IMAGES),
25 Ramble (TODDLE) on foot (TO-E) covering Dublin (-D-) to Donegal (-DL-) (TODDLE),
27 Caught short with no thoughts (‘caught short’ with no ‘thoughts’ = car = CAR) on The Road (CAR),
29 What’s great (G-) about (-RE-) head on wild (head on ‘Wild’ = -W) (GREW) rose? (rose = GREW),
30 For the observers following the spy (spy HOLES) from underground cells (HOLES),
31 Reviews (= reversal indicator) part of the hospital faculty (part of the ‘hospiTAL Faculty’ = talf = FLAT) where the nurses might be sharing (FLAT),
34 Jockey’s silks, for example (UNIFORM), in stable (stable/even = UNIFORM),
35 Some interloper at event (some ‘interlOPER AT Event’ = OPERATE) or function (OPERATE)
36 Presumably, you have to hand it to dad (PATERNITY TEST) signalling out the old man (PATERNITY TEST).
Down:
2 Is not professional (AMATEUR) from a (A-) mature (mature = -MATEUR) model (= anagram indicator) (AMATEUR),
3 Places to stay (INNS) for Mickey (Mickey Finn) and Huckleberry (Huckleberry Finn) heading off (f) (‘Finns’ without ‘f’ = INNS),
4 Odd (= anagram indicator) menu (menu = NU-ME-) includes tea (-T-) with little measure (gram = -G) (NUTMEG) of spice (NUTMEG),
5 English (E-) beers (ales = A-LES), including golf (-G-) (EAGLES), welcomed by the swingers of course (EAGLES),
6 One of those on the beer (FOAM) or fizz (FOAM),
7 Classified (ORDERED) by writer (-ED) coming after (= positional indicator) The Jesuits, for example (ORDER-) (ORDERED),
8 What the man of the cloth might do (what tailor might do = PATCH THINGS UP) to pour oil on troubled waters? (PATCH THINGS UP),
9 What you might need if you’re putting the boot in The Gloss (PATENT LEATHER) is obvious (PATENT) to hide (hide/skin = LEATHER) (PATENT LEATHER),
14 Old city (-UR-) in old South African province (Natal = NAT-AL) (NATURAL) is as normal as it gets (NATURAL),
16 Making (= anagram indicator) beer (beer = BERE-) – end product (end ‘producT’ = -T) (BERET) requires a nice (Nice/French) head to show it off perhaps (a Nice/French head to show off BERET),
18 It’s a mistake (ERROR) losing the head (t) with local rascal (‘terror’ without ‘t’ = ERROR),
20 Necessity to remove insect? (‘necessity’ to remove ‘insect’ = esy = YES) Absolutely! (YES),
21 Attaché caught up (= reversal indicator) (‘atTAChé’ = tac = CAT) with jazz fan (CAT),
24 Superpower (AMERICA) provides key (music key A-) to Crimea (Crimea = -MERICA) suffering (= anagram indicator) (AMERICA),
26 Lords and ladies dismissing dandies (‘lords and ladies’ dismissing ‘dandies’ = lorslad = DOLLARS) and bucks (DOLLARS),
27 State (= homophone indicator) regime change (‘coup’ = ‘coo’ = CO-O-) involves Frenchmen (Messieurs = -MM-) and new (-N) (COMMON) general (COMMON),
28 Endless (d) red (‘red’ without ‘d’ = RE-) wine (-PORT) (REPORT) to declare (REPORT),
32 Jobseeker dropping beers (‘jobseeker’ dropping ‘beers’ = joke = JOKE) is object of ridicule (JOKE),
33 Ran out of Antwerp (‘ran’ out of ‘Antwerp’ = twep = WEPT) and broke down (WEPT).