The winners of the FA Cup quarter-final replay between Arsenal and Chelsea will face Division One Sheffield United in the semi-finals.
The other semi-final will be contested by Watford and Southampton.
Victory for the two first division clubs would make history. Ever since the Football League was founded in 1888-89, the final has been contested by at least one team from the top flight.
Arsenal were held to a 2-2 draw by Chelsea in Saturday's quarter-final at Highbury, a re-run of last season's final, and must now face Claudio Ranieri's side again on March 25th at Stamford Bridge.
If Chelsea win the replay, Ranieri's side will be firm favourites to lift a third FA Cup in six years.
Southampton, whose only FA Cup victory came in 1976, will be strongly fancied to see off Watford, despite Ray Lewington's side having beaten two Premiership sides already this season (Sunderland and West Brom).
A win for Arsenal in their replay would line up a repeat of a memorable fifth round clash in 1999 when Arsenal won 2-1 but then agreed to a re-match because their winning goal against Sheffield United had been scored unsportingly.
Striker Nwankwo Kanu, making his debut for Arsenal, unwittingly intercepted Ray Parlour's throw-in towards the United keeper after their opponents had deliberately put the ball out of play to allow a player to receive treatment.
Kanu passed and Marc Overmars knocked the ball home, sparking furious protests. Arsenal won the re-match 2-1.
FA Cup semi-final draw
Watford v Southampton
Arsenal or Chelsea v Sheffield United.
Ties to be played on Sunday, April 13th