Six Nations team news:Scotland coach Andy Robinson has recalled Nick De Luca while his England counterpart Martin Johnson has dropped Lewis Moody for Saturday's Calcutta Cup clash at Murrayfield.
De Luca will play at outside centre in the only personnel change to the side beaten in Italy 10 days ago. Max Evans moves to the wing, with Simon Danielli dropping to the bench.
De Luca, who will win his 16th cap this weekend, has not started for Scotland since the victory over Canada at Pittodrie in November 2008, although the 26-year-old Edinburgh star did come off the bench in Rome.
Captain Chris Cusiter has shaken off a virus and flanker John Barclay has recovered from a knee injury to start.
But injuries have forced changes on the bench, with Mike Blair, Alasdair Strokosch and Alasdair Dickinson all ruled out.
Edinburgh scrumhalf Blair and Gloucester prop Dickinson both suffered concussion playing for their clubs on Sunday, while Strokosch suffered a recurrence of an ankle injury.
That means substitute roles for Rory Lawson, Geoff Cross and Alan MacDonald.
Robinson, who has lost all three of his Six Nations matches in charge ahead of this weekend's meeting with his former employers, said: "The team has played some good rugby and we have been creating chances. We just need to take that next step and finish off a game."
Of Evans playing out of position on the wing, he added: "Max has been our most potent attacker and we also want to see Nick and the qualities that he can bring to this game."
Moody was withdrawn after 55 minutes during the defeat to Ireland and has been replaced at openside flanker by Joe Worsley.
Worsley (32) returns to the starting XV for the first time since suffering knee ligament damage in the opening minute of England's 19-6 defeat to New Zealand in November.
Johnson has made just one other enforced change to the starting XV, with Louis Deacon replacing the injured Simon Shaw in the secondrow.
Northampton's versatile lock Courtney Lawes comes onto a reshuffled bench which features a return for hooker Steve Thompson and a first call-up for the uncapped Leicester scrumhalf Ben Youngs.
The 20-year-old has replaced Paul Hodgson, who he played against on Saturday in Leicester's 35-19 Premiership victory over London Irish.
Youngs' father, Nick, won six caps for England at scrumhalf between 1983 and 1984.
England have lost on each of their last two visits to Murrayfield and Saturday's game marks the 20-year anniversary of Scotland's 13-7 Grand Slam-clinching victory.
Teams
Scotland: Hugo Southwell, Sean Lamont, Nick De Luca, Graeme Morrison, Max Evans, Dan Parks, Chris Cusiter (capt), Johnnie Beattie, John Barclay, Kelly Brown, Alastair Kellock, Jim Hamilton, Euan Murray, Ross Ford, Allan Jacobsen. Replacements: Scott Lawson, Geoff Cross, Nathan Hines, Alan MacDonald, Rory Lawson, Phil Godman, Simon Danielli.
England: Delon Armitage, Mark Cueto, Mathew Tait, Riki Flutey, Ugo Monye, Jonny Wilkinson, Danny Care, Nick Easter, Joe Worsley, James Haskell, Steve Borthwick (capt), Louis Deacon, Dan Cole, Dylan Hartley, Tim Payne Replacements: Steve Thompson, David Wilson, Courtney Lawes, Lewis Moody, Ben Youngs, Toby Flood, Ben Foden