England could be deprived of Jason Robinson and Neil Back for their Six Nations meeting with Italy next month after both players went off during Saturday's 26-9 victory over Wales in Cardiff.
Full-back Robinson has twisted a knee, while flanker Back hurt his calf, giving England coach Clive Woodward further fitness worries during a campaign already riddled by injuries.
Props Jason Leonard (hamstring), Julian White (knee) and Phil Vickery (back) are all unlikely to feature in the remaining games against Italy, Scotland and Ireland, while flanker Lewis Moody (shoulder) will see a specialist on Tuesday.
But fly-half Jonny Wilkinson and wing Dan Luger, who also departed the Millennium Stadium action early, should be fit for Italy.
"Jason Robinson and Neil Back are concerns," admitted Woodward, whose lengthy casualty list additionally includes Matt Dawson, Austin Healey and Iain Balshaw.
Should Robinson be ruled out against Italy at Twickenham on March 9, the number 15 jersey could be contested by Wasps back Josh Lewsey and Leicester's Tim Stimpson. Joe Worsley and Alex Sanderson provide clear alternatives in Back's possible absence.
But it looks as if Wilkinson, England's key man with 36 of his team's 51 points in the championship to date, will be fit for the Italy encounter after suffering a knee problem.
"I came off as a precaution at the end, and it feels a lot better now," said Wilkinson.
"I am pretty sure I will be fit for next weekend. We will have a look at things when I get back up to Newcastle, but it feels as if it will be okay."