Manchester United manager Alex Ferguson makes five changes for the visit of Dynamo Kiev in Group F of the Champions League, with Daniel Simpson a surprise starter at right-back.
Wes Brown is dropped to the bench - as is Anderson - to give 20-year-old Simpson his first European start.
Of the players who drew 2-2 with Arsenal on Saturday there is no place in the squad for Rio Ferdinand, on his 29th birthday, Owen Hargreaves or Ryan Giggs.
Gerard Pique is brought in to partner Nemanja Vidic in central defence, with Michael Carrick, Darren Fletcher and Nani the replacements in midfield.
Kiev are boosted by the presence of Sergiy Rebrov among the substitutes after the former Tottenham striker recovered sufficiently from a knee injury.
Theo Walcott is handed another chance to impress as Arsenal look to book their place in the last 16 of against Group H rivals Slavia Prague.
The England starlet netted a brace as the Czech league leaders were destroyed 7-0 at Emirates Stadium a fortnight ago, and comes into the starting XI with eight changes from the side which drew 2-2 with United on Saturday.
Croatia striker Eduardo and Nicklas Bendtner lead the attack, with Emmanuel Adebayor on the bench.
Alex Song comes into the defence to replace injured Kolo Toure, while experienced midfielder Gilberto is alongside compatriot Denilson in the absence of rested Cesc Fabregas as the Gunners look to extend their unbeaten run to 26 games.
Slavia - who trail second-placed Sevilla by three points - have former Liverpool midfielder Vladimir Smicer available again following his long injury lay-off.
Michal Vorel makes his Champions League debut in goal, replacing Czech international Martin Vaniak - who was beaten seven times in London as the Gunners maintained their 100 per cent European record.
Man Utd:Van der Sar, Simpson, Vidic, Pique, Evra, Ronaldo, Carrick, Nani, Fletche, Rooney, Tevez. Subs: Kuszczak, Brown, Anderson, Saha, O'Shea, Evans, Eagles.
Dynamo Kiev:Shovkovskiy, Fedoriv, Vashchuk, El Kaddouri, Markovic, Diakhate, Rotan, Correa, Gusev, Ghioane, Milevskiy. Subs: Rybka, Rebrov, Bangoura, Rincon, Gavrancic, Ninkovic, Dopilka.
Slavia Prague:Vorel, Tavares, Hubacek, Drizd'al, Brabec, Smicer, Svec, Pudil, Suchy, Krajcik, Senkerik. Subs: Vaniak, Gaucho, Sourek, Ivana, Belaid, Kalivoda, Jablonsky.
Arsenal:Almunia, Diarra, Gallas, Song Billong, Clichy, Walcott, Silva, Denilson, Diaby, Eduardo, Bendtner. Subs: Lehmann, Sagna, Flamini, Adebayor, Eboue, Traore, Justin Hoyte.