Four suspected cases of foot-and-mouth disease have been detected in Holland.
Preliminary results on four cows have shown signs of the disease, the agriculture ministry said.
More tests are being done and the final results will be available on Friday.
The ministry said four companies that had handled the animals were under observation and the area around them was closed for a six-mile radius.
About 300 cattle and four goats are to be destroyed on Wednesday as a precautionary measure.
The animals were on a farm in the eastern part of the country in the province of Gelderland.
On Monday the government lifted six-day-old restrictions on transporting cloven-hoofed animals to slaughterhouses, except in a small area of Gelderland.
The ministry said there was no immediate plan to re-impose the restrictions.
PA