Good for a laugh

Question: "What do you give the man who has everything?"

Question: "What do you give the man who has everything?"

Answer: "Antibiotics."

This joke was included in a battery of jokes used by researchers Vinod Goel and Raymond Dolan to tickle the funny bones of 14 volunteers while their brains were scanned using a technique called functional magnetic resonance imaging. The work of Goel and Dolan is published in Nature Neuroscience, Vol. 4, 237-238 (2001).

One aim of the research was to identify which parts of the brain process two types of jokes - phonological jokes (puns - related to sounds) and semantic jokes (related to meanings of words). The antibiotics joke is semantic. One of the phonological jokes used was:

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Question: "Why did the golfer wear two pairs of pants?" Answer: "He got a hole in one."

The research found that semantic jokes are processed by areas of the brain (bilateral posterior, inferior temporal lobes) involved in the semantic processing of language. Phonological jokes are processed in areas of the brain known to be involved in speech production (left inferior pre-frontal cortex and insula).

However, it was further noted that both types of joke also activate the median ventral pre-frontal cortex, an area of the brain known to represent and control reward-related behaviour. The extent of activation of this region also correlated positively with the volunteers' ratings of the funniness of the jokes. It seems that the brain feels rewarded by finding something funny, and this lends credence to the idea that laughter is therapeutic.

In contrast, no increased activity was seen in these various brain regions when the punch lines of the jokes were changed to logical statements such as: "Why did the golfer wear two pairs of pants? . . . It was a very cold day."

Think about the structure of a typical joke. The set-up part of the joke focuses your mind in one direction. Then the punchline suddenly snaps you into another direction. Goel and Dolan were particularly interested in studying this lateral thinking shift which takes place in the brain's processing of humour. The research showed that the functional brain anatomy correlated with the lateral shift is different than previously thought. Overall, this research contributes significantly to our understanding of brain organisation and function.

When we find something funny, we spontaneously laugh. Aristotle claimed that people are the only animals which laugh, but we now know that laugh-like behaviour is common in other primate species, too. Chimpanzees make rhythmic noises when playing and, although the noises sound more like pants than chuckles, sound analysis suggests that the chimps are vocalising their "ho-hos" while inhaling as well as exhaling. People vocalise laughter only during exhalation.

Laughter is contagious. The prime example of this characteristic has to be from Kashasha, a village near Lake Victoria. On January 30th 1962, three girls at a missionary school began giggling uncontrollably. Classmates joined in, some having laughing bouts lasting for hours, making studies impossible. Laughing spread over the following weeks until the school had to be closed on March 18th with two-thirds of the girls convulsed.

The epidemic spread far beyond the school. Laughter rang out from houses and public gatherings were hilarious affairs. Quarantine was imposed and laughing villagers were not allowed to leave home even on serious business. At the peak of the laughing epidemic, over 1,000 people were afflicted and over 14 schools were closed. The area was not declared laughter-free until June 1964.

My most vivid personal memory of contagious laughter is of the sharpest and most cutting theatre revue I ever heard. It happened when I was a schoolboy. There were two boys' secondary schools in our town. The neighbouring school to mine was visited by an actor of some note who had agreed to perform Shakespearian recitations for the boys. Our school was invited to send over about 15 boys to share in this treat. I was one of the boys selected.

The performance was stagey and heavy and made no concessions to the fact that we were rough-and-ready schoolboys. We applauded politely after each recitation and the actor warmed to his task. And then it happened. In the middle of an emotional soliloquy he took a long pause for effect in the middle of which we were treated to a low, rumbling sound of breaking wind from one of the lads at the back. Someone ventured a nervous laugh, and that was it - immediately we were all in unstoppable convulsions. The performance, of course, had to end. When we got back to our own school the word spread like wildfire and pretty soon the whole school was laughing.

Now I will treat you to a selection of the jokes used by Goel and Dolan in their recent study, starting with pokes at two professions.

Question: "Why don't sharks bite lawyers?"

Answer: "Professional courtesy."

Question: "What do engineers use for birth con- trol?"

Answer: "Their personalities."

Question: "Where can you find a turtle with no legs?"

Answer: "Right where you left him."

Question: "If you have spots before your eyes, shouldn't you see a doctor?"

Answer: "No, only spots."

Question: "Which side of a dog usually has the most hair?"

Answer: "The outside."

Question: "What did the grape say when he was sat on?"

Answer: "Nothing, he just let out a little whine."

I will leave you with one final joke of my own. A science-columnist walked into a bar with a chicken under his arm. "Hey", said the barman, "where did you get him?"

"Down at the market", said the chicken.

William Reville is a Senior Lecturer in Biochemistry and Director of Microscopy at UCC.