Champions League team-news: Liverpool are forced to face Real Betis without their Spanish duo of Xabi Alonso and Luis Garcia after both failed to recover from injuries sustained during the defeat of Portsmouth on Saturday.
Boss Rafael Benitez also leaves out Djibril Cisse for the Champions League tie, allowing Fernando Morientes to start up front alongside Peter Crouch, still searching for his first goal after 19 hours and 45 minutes of action.
John Arne Riise starts at full-back with Mohamed Sissoko returning to midfield, with Harry Kewell and Cisse on the bench for a Group G game that sees Liverpool needing just a point to reach the last 16 of the Champions League.
Real Betis, without injured strikers Ricardo Oliveira and Dani, show just two changes from the side beaten by Liverpool in Seville in the first game of the group.
Xisco Munoz starts up front with Alberto Rivera in midfield. Edu's ankle injury allows him only a place on the bench.
Chelsea manager Jose Mourinho resists the temptation to give a full debut to youngster Lassana Diarra away to Anderlecht.
Instead, he makes just two changes from the side that destroyed Newcastle on Saturday.
William Gallas returns at right-back in place of injured Glen Johnson and Michael Essien replaces Claude Makelele, who sustained a knee injury in the game with Newcastle.
Liverpool:Reina, Finnan, Carragher, Hyypia, Riise, Gerrard, Hamann, Sissoko, Zenden, Crouch, Morientes. Subs: Dudek, Kewell, Cisse, Josemi, Traore, Warnock, Potter.
Real Betis:Doblas, Melli, Juanito, Rivas, Oscar Lopez, Joaquin, Assuncao, Rivera, Arzu, Xisco, Fernando. Subs: Contreras, Canas, Capi, Castellini, Edu, Juanlu, Israel.
Anderlecht:Proto, Deschacht, Tihinen, Kompany, Zewlakow, Goor, Vanderhaeghe, Vanden Borre, Akin, Mpenza, Wilhelmsson. Subs: Zitka, Juhasz, Ehret, Zetterberg, Iachtchouck, Deman, Mitu.
Chelsea:Cech, Del Horno, Terry, Ricardo Carvalho, Gallas, Duff, Essien, Lampard, Joe Cole, Crespo, Gudjohnsen. Subs: Cudicini, Carlton Cole, Geremi, Drogba, Diarra, Paulo Ferreira, Huth.