Arsenal (2) v Bolton (5):Arsenal will be without defender Thomas Vermaelen (Achilles) but will have midfielder Samir Nasri available again following knee surgery.
Forward Theo Walcott is out for up to six weeks after suffering an ankle injury while on duty for England in midweek, and Holland forward Robin van Persie (ankle) is still not fit. Sebastien Squillaci is set for his debut in central defence, while midfielder Denilson returns after an abdominal injury. However, Nicklas Bendtner (groin) and Aaron Ramsey (leg) remain out.
Bolton manager Owen Coyle will hand goalkeeper Adam Bogdan his first Premier League start. The Hungarian replaces Jussi Jaaskelainen, who is suspended after being sent off in the 2-2 draw against Birmingham. Coyle will monitor the fitness of striker Ivan Klasnic, who missed that match because of a thigh strain.
Last season: Arsenal 4 Bolton 2, Bolton 0 Arsenal 2
Last five league matches: Arsenal L W D W W; Bolton L W D W D
Top scorers (all competitions): Theo Walcott (Arsenal) 4; Johan Elmander (Bolton) 2
Match odds: H 1-5 A 14-1 D 5-1
Referee: Stuart Attwell (Warwickshire)
Everton (18) v Man Utd (3)
Everton have problems up front with Louis Saha (calf) been ruled out for three weeks while Victor Anichebe (knee) remains doubtful. With another forward, James Vaughan, now on loan at Crystal Palace, Jermaine Beckford is certain to start as he continues his search for a first top-flight goal. Midfielder Jack Rodwell (ankle) is out for up to three months but captain Phil Neville (foot) is back in training and could return to face his old club.
Alex Ferguson must decide whether to let Wayne Rooney run the gauntlet of hate at Goodison Park. Rooney is due to face former club Everton after a difficult week following the allegations about his private life. Rio Ferdinand could make his first appearance of the season after recovering from a knee injury, while the fitness of Javier Hernandez and Antonio Valencia will need to be assessed after their late return from international duty.
Last season: Everton 3 Man Utd 1, Man Utd 3 Everton 0
Last five league matches: Everton D W L D L; Man Utd W W W D W
Top scorers (all competitions):Tim Cahill, Jermaine Beckford, Louis Saha, Marouane Fellaini, Jack Rodwell & Leon Osman (Everton) 1; Dimitar Berbatov (Man Utd) 3
Match odds: H 16-5 A 10-11 D 23-10
Referee: Martin Atkinson (W Yorkshire)
Fulham (14) v Wolverhampton (7)
Bobby Zamora is available after recovering from a thigh injury. New signing Carlos Salcido will not be considered due to visa delays and Damien Duff is a doubt because of a calf problem. Keeper Mark Schwarzer will start after overcoming his back problem but back-up stopper David Stockdale will be out for up to a month with an ankle injury.
Wolves will include Marcus Bent in their squad for the first time. The striker was signed on loan from Birmingham before the transfer window closed. Jelle Van Damme has recovered from an ankle injury but fellow defender Ronald Zubar is ruled out of the clash with the Cottagers with a hamstring injury.
Last season: Fulham 0 Wolverhampton 0, Wolverhampton 2 Fulham 1
Last five league matches: Fulham L L D D D; Wolverhampton L W W D D
Top scorers (all competitions): Bobby Zamora (Fulham) 3; Sylvan Ebanks-Blake (Wolverhampton) 2
Match odds: H 5-6 A 7-2 D 12-5
Referee: Phil Dowd (Staffordshire)
Man City (9) v Blackburn (15)
City captain Carlos Tevez faces a late fitness test - he suffered a knock in midweek when Argentina defeated Spain in a friendly. Micah Richards is in contention for a place after shaking off a chest infection, but Mario Balotelli, Aleksandar Kolarov, Jerome Boateng and Wayne Bridge remain sidelined through injury.
Blackburn boss Sam Allardyce could give a debut to former Manchester City striker Benjani Mwaruwari . The Zimbabwean was released by City at the end of last season but earned a one-year contract at Rovers after training with the squad over the summer. Keith Andrews (groin) remains sidelined while Martin Olsson is a doubt with a shoulder problem but striker Jason Roberts returns to the squad after resolving his differences with Allardyce.
Last season: Man City 4 Blackburn 1, Blackburn 0 Man City 2
Last five league matches: Man City L D D W L; Blackburn W W W L L
Top scorers (all competitions): Carlos Tevez (Man City) 2; Mame Diouf (Blackburn) 4
Match odds:H 1-3 A 8-1 D 4-1
Referee: Mark Clattenburg (Tyne & Wear)
Newcastle (8) v Blackpool (12)
Newcastle boss Chris Hughton could hand debuts to three of his summer signings. Sol Campbell, Cheik Tiote and Hatem Ben Arfa are all available for the first time. Striker Andy Carroll has resumed training after an ankle injury and Hughton will assess him before making his selection. Spanish striker Xisco begins a three-match ban following his sending-off for the reserves and Steven Taylor (shoulder), Danny Simpson and Leon Best (both ankle) are also out, while knee injuries rule out Danny Guthrie and Dan Gosling.
Blackpool hope to welcome back Marlon Harewood, who is back in training after sitting out the home draw with Fulham due to an ankle injury. Former Leicester front man DJ Campbell might be handed a place in the starting line-up but Alex Baptiste is ruled out with a fractured hand.
Last season: No corresponding fixture
Last five league matches: Newcastle D W L W D; Blackpool W D W L D
Top scorers (all competitions): Andrew Carroll (Newcastle) 4; Marlon Harewood & Ludovic Sylvestre (Blackpool) 2
Match odds: H 8-13 A 9-2 D 11-4
Referee: Lee Mason (Lancashire)
West Brom (16) v Tottenham (11)
West Brom could be without creative midfielder Graham Dorrans who is fit but may not play due to what manager Roberto Di Matteo calls “personal reasons”. Fellow midfielder James Morrison is suspended after being sent of in the defeat at Anfield but Jerome Thomas may return after recovering from a foot injury. Defender Joe Mattock (foot), striker Ishmael Miller (thigh) and defender Marek Cech (foot) miss out but Paul Scharner could be in line for a debut.
New signings Rafael van der Vaart, William Gallas, Sandro and Stipe Pletikosa could all make their Spurs debuts. Jermain Defoe and Michael Dawson are both out for several weeks with damaged ligaments, Heurelho Gomes (groin) is unlikely to be fit, while Jamie O’Hara (back) and Jonathan Woodgate (groin) are long-term absentees. Peter Crouch (back), Luka Modric (groin) and David Bentley (ankle) have recovered.
Last season: No corresponding fixture
Last five league matches: West Brom D D L W L; Tottenham W L D W L
Top scorers (all competitions): Chris Wood, Peter Odemwingie & Ibanez Pablo (West Brom) 1; Peter Crouch (Tottenham) 3
Match odds: H 5-2 A 21-20 D 12-5
Referee: Howard Webb (S Yorkshire)
West Ham (20) v Chelsea (1)
Avram Grant could hand West Ham debuts to striker Victor Obinna and right-back Lars Jacobsen. Robert Green has recovered from hip surgery and is expected to start but there are doubts over Thomas Hitzlsperger and Danny Gabbidon who are struggling with thigh and hamstring injuries respectively. Valon Behrami is likely to make his first appearance of the season after overcoming a thigh injury.
John Terry has been passed fit after suffering a hamstring injury but Frank Lampard still needs more time to recover from hernia surgery. Young France international Gael Kakuta is included in the Chelsea squad and new signing Ramires could be given his first start since joining from Benfica.
Last season: Chelsea 4 West Ham 1, West Ham 1 Chelsea 1
Last five league matches: West Ham L D L L L; Chelsea W W W W W
Top scorers (all competitions): Mark Noble & Scott Parker (West Ham) 1; Florent Malouda & Didier Drogba (Chelsea) 4
Match odds: H 8-1 A 1-3 D 4-1
Referee: Chris Foy (Merseyside)
Wigan (17) v Sunderland (10)
Charles N’Zogbia is set for a possible Wigan return after he was left out of the 1-0 win at Tottenham following the breakdown of his proposed transfer to Birmingham. Goalkeeper Chris Kirkland is available having also missed the victory at White Hart Lane due to a hip problem, while striker Victor Moses, who has been nursing an ankle injury, is rated at 50-50 to take part. New signings Franco Di Santo and Tom Cleverley could both be in line for their debuts.
Sunderland could give a league debut to record signing Asamoah Gyan who is available for the first time since completing his £13million-plus switch from French club Rennes. He could replace Fraizer Campbell, who will undergo surgery to repair his damaged cruciate ligament next Friday. Nedum Onuoha is available again after being ineligible for the 1-0 win over parent club Manchester City and John Mensah (hamstring) is fit, while both Andy Reid and George McCartney have two reserve games under their belt and return to contention.
Last season: Sunderland 1 Wigan 1, Wigan 1 Sunderland 0
Last five league matches: Wigan D L L L W; Sunderland L L D L W
Top scorers (all competitions): Victor Moses, Jordi Gomez & Hugo Rodallega (Wigan) 1; Darren Bent (Sunderland) 4
Match odds: H 6-4 A 9-5 D 9-4
Referee: Peter Walton (Northamptonshire)
Sunday, September 12
Birmingham (6) v Liverpool (13)
New signing Alexander Hleb faces a wait for his Birmingham debut after suffering a leg injury when on duty for Belarus in their mid-week Euro 2012 qualifier with Romania. Fellow transfer deadline signings Jean Beausejour and Martin Jiranek will come into contention. Veteran striker Kevin Phillips (calf) and defender Stuart Parnaby (hamstring) are not yet ready to return for the unbeaten Blues.
New Liverpool signings Paul Konchesky and Raul Meireles are set to make their first appearances in Roy Hodgson’s squad. Left-back Konchesky is likely to start but Meireles may have to settle for a place on the bench having been away with Portugal. Forward Dirk Kuyt is out with a shoulder injury sustained while away with the Netherlands while Joe Cole serves the final game of his three-match suspension. Striker David Ngog has recovered from a hamstring injury.
Last season: Birmingham 1 Liverpool 1, Liverpool 2 Birmingham 2
Last five league matches: Birmingham W L D W D; Liverpool L D D L W
Top scorers (all competitions): Craig Gardner (Birmingham) 3; David Ngog (Liverpool) 4
Match odds: H 23-10 A 6-5 D 9-4
Referee: Mark Halsey (Lancashire)
Monday, September 13
Stoke (19) v Aston Villa (4)
Stoke have summer signing Kenwyne Jones fit to start after fully recovering from an ankle injury on the opening day of the season. Goalkeeper Thomas Sorensen is hopeful of being able to play after missing Denmark’s Euro 2012 qualifier on Tuesday because of an infection in an elbow problem he sustained against Wolves. Transfer deadline day signings Eidur Gudjohnsen, Jermaine Pennant and Marc Wilson may have to settle for a place on the bench.
Aston Villa will check on the fitness of midfielder Stephen Ireland who suffered a hamstring injury during the warm-up to the Everton clash a fortnight ago. Midfielder Steve Sidwell could come into contention. Defender James Collins is expected to be fit after suffering a severe black eye when on duty for Wales against Montenegro last weekend. Kevin MacDonald will be in charge as caretaker manager for the final time before Gerard Houllier officially takes command.
Last season: Stoke 0 Aston Villa 0, Aston Villa 1 Stoke 0
Last five league matches: Stoke W L L L L; Aston Villa L L W L W
Top scorers (all competitions): Tuncay Sanli, Abdoulaye Faye, Ricardo Fuller & Jonathan Walters (Stoke) 1; Gabriel Agbonlahor, Barry Bannan, Luke Young, Emile Heskey, Stewart Downing & Stiliyan Petrov (Aston Villa) 1
Match odds: H 6-4 A 9-5 D 9-4
Referee: Lee Probert (Wiltshire)