Ryanair has pulled out of its proposed new route from London Stansted to Grenoble due to contractual difficulties with the French airport.
Announcing the closure of the route, Ryanair's deputy chief executive, Mr Michael Cawley, said: "We sincerely regret closing the route to Grenoble but unfortunately the attitude of the airport authorities there gave us no alternative".
He said Ryanair already flies to St Etienne in the Rhone Alp region and will be offering existing passengers either a refund or the offer of a transfer to another route.
Mr Cawley said the airport management and the region have been unable to deliver on terms envisaged in the original agreement with Ryanair.
"We sincerely apologise to all of those passengers inconvenienced by this decision," Mr Cawley said.