Treating critically ill Covid-19 patients with corticosteroid drugs reduces the risk of death by 20 per cent, an analysis of seven international trials found on Wednesday. This finding prompted the World Health Organisation to update its advice on treatment.
The analysis – which pooled data from separate trials of low dose hydrocortisone, dexamethasone and methylprednisolone – found that steroids improve survival rates of Covid-19 patients sick enough to be in intensive care in hospital.
“This is equivalent to around 68 per cent of [the sickest Covid-19] patients surviving after treatment with corticosteroids, compared to around 60 per cent surviving in the absence of corticosteroids,” said the researchers.
“Steroids are a cheap and readily available medication. And our analysis has confirmed that they are effective in reducing deaths among the people most severely affected by Covid-19,” said Jonathan Sterne, a professor of medical statistics and epidemiology at Britain’s Bristol University who worked on the analysis.
He said the trials – conducted by researchers in Britain, Brazil, Canada, China, France, Spain, and the United States – gave a consistent message throughout, showing the drugs were beneficial in the sickest patients regardless of age or sex or how long patients had been ill.
The findings, published in the Journal of the American Medical Association, reinforce results that were hailed as a significant breakthrough and announced in June, when dexamethasone became the first medicine shown to be able to reduce death rates among severely sick patients from the virus.
Dexamethasone has been in widespread use in intensive care wards treating Covid-19 patients in some countries since then.
Martin Landray, a professor of medicine and epidemiology at the University of Oxford who worked on the dexamethasone trial that was a key part of the pooled analysis published on Wednesday, said the results mean doctors in hospitals worldwide can safely switch to using the drugs to save lives.
Clear benefits
“These results are clear, and instantly usable in clinical practice,” he told reporters. “Among critically ill patients [with the virus] low-dose corticosteroids . . . significantly reduce the risk of death.”
Researchers said the benefit was shown regardless of whether patients were on ventilation at the time they started treatment. They said the WHO would update its guidelines immediately to reflect the fresh results.
Until the June findings on dexamethasone, no effective treatment had been shown to reduce death rates in patients with Covid-19, the respiratory disease caused by the new coronavirus.
More than 25 million people have been infected with the virus and in excess of 850,000 have died, according to a Reuters tally.
Gilead Sciences remdesivir was authorised by United States regulators in May for use in patients with severe Covid-19 after trial data showed the antiviral drug helped shorten hospital recovery time.
Anthony Gordon, an Imperial College London professor who also worked on the analysis, said its results were good news for patients who become critically ill with the disease, but would not be enough to end outbreaks or ease infection control measures.
“Impressive as these results are, this is not a cure. We now have something that will help, but it is not a cure, so it’s vital that we keep up all the prevention strategies.” – Reuters