Belfast Harlequins possessed too much pace, power and organisation for the visitors at Deramore Park last night.
The home side, playing with the benefit of a strong wind, ran in 15 unanswered first-half points.
Ian Humphreys put them in front with a fifth-minute penalty and 'Quins extended their lead with a try by wing Paul McKenzie after several phases of attacking the narrow channel.
Chris McCarey drove over from an attacking scrum in the 39th minute. Chris McCarey's try soon after the restart put the game beyond doubt even though flanker Hugh Hogan hit back with a 53rd-minute try.
Humphreys added two more penalties before Dublin University had the final say with a try by Martin Garvey.
BELFAST HARLEQUINS: J Lowe; P McKenzie, G Mitchell, WP Strauss, C Aktinson; I Humphreys, R Spee; J Carey, N Hanna, D Fitzpatrick, L Magowan, L Stevenson, D Barbour, C McCarey, S Lamb.
DUBLIN UNIVERSITY: S Mitchell; P Howard, B Hastings, J Quigley, B Canavan; (B Kinsella 23) D Crotty, P McCormack; N Conlon (D Rowe 55), M Crockett, E McBennett, M Garvey, M Warburton, E Molloy, H Hogan, D Hayes.
Referee: G Clancy (Munster)
