Southampton can add English League Cup disaster to Premiership misery after Second Division Fulham knocked them out of the second round at The Dell last night. Without a win this season, the Saints are still suffering after German striker Dirk Lehmann struck the only goal of the night to earn a 2-1 aggregate success for Fulham boss Kevin Keegan against his old club.
Dave Jones' side also had Carlton Palmer sent off for a needless tackle on the goalscorer, who found the net in the 10th minute after being set up by former England striker Peter Beardsley.
Tottenham finally polished off a spirited Brentford side but not before a tough struggle at White Hart Lane.
Trailing 3-2 from the first leg at Griffin Park, former Sheffield United striker Andy Scott levelled the aggregate scores for the Bees in the first minute.
But Allan Nielsen restored Spurs' overall lead at 4-3 before Sol Campbell and Chris Armstrong, who needed stitches in a head wound in the first half, finally established Spurs' superiority with second-half goals.
Lloyd Owusu pulled another goal back for the Third Division side but Spurs moved through to the third round of the Cup 6-4 over the two legs.
Everton also came from behind to save more Premiership blushes with goals from French midfielder Olivier Dacourt and Italian defender Marco Materazzi giving them a 2-1 win at Goodison.
Huddersfield took the lead at Goodison after only 44 seconds when in-form striker Marcus Stewart made it 2-1 on aggregate to the First Division pacesetters.
But Dacourt replied with a stinging freekick and Materazzi put Everton ahead three minutes before half-time with a cheeky backheel as Walter Smith's side scraped through 3-2 overall.
Materazzi blotted his copybook though by being sent off for a challenge on Stewart with 20 minutes left on the clock.
Manchester City's hopes of upsetting Derby at Maine Road following the 1-1 draw at Pride Park floundered on a goal from Costa Rican star Paulo Wanchope.
Wanchope's looping shot deflected off City defender Tony Vaughan and into the net to seal City's fate with a 2-1 defeat over the two legs.
City were denied a penalty when Lee Bradbury turned away from Jacob Laursen in the box and was wrestled to the ground, only for referee Neale Barry - just 10 yards away - to wave play on to the fury of an astonished Maine Road crowd.
The one thing Joe Royle's sides do not tolerate is lack of sweat, and City produced that in abundance in the second period. They confronted Derby rather than concede space and possession, even if they could not match the skill level when Derby put their mind to it.
Chinese star Fan Zhiyi scored his first goal for Crystal Palace but Terry Venables' men bowed out of the Cup 4-2 on aggregate against First Division rivals Bury.
Palace had high hopes of a comeback when Clinton Morrison opened the scoring as they tried to overhaul a 3-0 first-leg deficit.
The former Eagles trainee launched his side's fight-back with an eighth-minute strike only to score an own goal 17 minutes later to make it 4-1 to Bury.
Fan Zhiyi scored with 13 minutes remaining but by then it was too late for the Selhurst Park side who lost 4-2 on aggregate.
Barnsley drew 1-1 with Reading at the Madejski Stadium to preserve their three-goal advantage from the first leg at Oakwell and go through 4-1.
Ashley Ward scored for the Tykes and Darren Caskey equalised for the home side, but it will be Barnsley in the hat for Saturday's lunchtime third round draw.