Ulster scrum-half Isaac Boss will lead Ireland A against Scotland A in Perth.
Boss is one of three members of Ireland's ill-fated World Cup squad who will be in action against the Scots' second string on Friday.
Provincial colleague Stephen Ferris has been picked at number eight, with Frankie Sheahan of Munster starting at hooker.
Boss links up at half-back with another Ulsterman Niall O'Connor, who has been handed the number 10 jersey.
Leinster's Luke Fitzgerald is included at outside centre but will be called up for the RBS 6 Nations clash with Scotland if Brian O'Driscoll fails to recover from his calf injury.
Ireland coach Eddie O'Sullivan said: "For the last A game, I felt there were a few senior guys who needed some game time under their belts.
"But the A team is very important for development, so this time I thought we'd be better off seeing a young guy getting a chance.
"It is a mixed bag. An example of this is Niall O'Connor, a young guy who I thought played very well up at Ravenhill at the weekend."
Ireland A team:D Riordan (Connacht); I Dowling, (Munster), K Lewis (Leinster), G Duffy (Connacht), G Brown, (Leinster); N O'Connor (Ulster), I Boss (Ulster, captain); C Healy (Leinster), F Sheahan (Munster), D Fitzpatrick (Ulster), T Hogan (Leinster), R Caldwell (Ulster), S Keogh, (Leinster), N Ronan (Munster), S Ferris (Ulster).
Replacements:A Flavin/John Fogarty, M Ross (Harlequins), D Ryan (Munster), D Pollock (Ulster), C Keane (Leinster), A Dunne (Leinster), K Earls (Munster).