Guy Easterby will make his 60th appearance for Leinster when they look to do the double over Edinburgh in Murrayfield on Saturday.
The former Ireland international was drafted back into the Leinster squad on a short term contract earlier in the week and immediately takes the place of scrumhalf Cillian Willis.
The 36-year-old will be partnered at halfback by Felipe Contepomi, while Girvan Dempsey's return at fullback pushes Rob Kearney to the wing and Luke Fitzgerald to the bench.
In the pack, Shane Jennings gets the nod ahead of Keith Gleeson while player of the month Bernard Jackman is named in an unchanged frontrow with props Stan Wright and Ollie Le Roux.
Gleeson, Jonathan Sexton, and Cameron Jowitt join Fitzgerald among the replacements.
Michael Cheika's side are likely to face a sterner test than they did in the RDS last week, when they failed to register a bonus point in a 28-14 win.
Leinster: Girvan Dempsey, Shane Horgan, Brian O'Driscoll(c), Gordon D'Arcy, Rob Kearney; Felipe Contepomi, Guy Easterby; Ollie le Roux, Bernard Jackman, Stan Wright; Leo Cullen, Malcolm O'Kelly; Stephen Keogh, Shane Jennings, Jamie Heaslip
Replacements: Brian Blaney, Cian Healy, Cameron Jowitt, Keith Gleeson, Chris Keane, Jonathan Sexton, Luke Fitzgerald
