Friday
Southampton (14) v Aston Villa (15), 8pm - Live on Sky Sports
Southampton forward Armando Broja is back in contention after missing two matches with an ankle problem. Midfielder Moussa Djenepo also returns to the squad leaving defender Jack Stephens (knee) as the only absentee.
Ezri Konsa is suspended for Villa, meaning a likely recall for Tyrone Mings, and Danny Ings (muscle injury) has lost his battle to return against his former club. Jacob Ramsey (ankle) could be fit while Morgan Sanson returns to contention after recovering from Covid-19. Douglas Luiz (muscle injury) remains out.
Last season: Southampton 0 Aston Villa 1, Aston Villa 3 Southampton 4
Last five league matches: Southampton L L W D W; Aston Villa W L L L L
Top scorers (all competitions): Mohamed Elyounoussi and Armando Broja (Southampton) 4; Danny Ings (Aston Villa) 3
Match odds: H 21-20 D 5-2 A 13-5
Referee: Andrew Madley
Saturday (3pm unless stated)
Man Utd (5) v Man City (3), 12.30pm - Live on Sky Sports
Manchester United have defensive issues with Raphael Varane out for up to five weeks with a hamstring injury while Victor Lindelof faces a fitness test on the knock that forced him to miss Tuesday’s 2-2 draw with Atalanta. Paul Pogba serves the second game of a three-match domestic ban but Fred should return in midfield.
City centre-back Aymeric Laporte is suspended after being sent off in last week’s loss to Crystal Palace. Manager Pep Guardiola will also check on Kyle Walker (foot) while winger Ferran Torres (foot) is City’s only other notable absentee.
Last season: Man City 0 Man Utd 2, Man Utd 0 Man City 0
Last five league matches: Man Utd L D L L W; Man City W D W W L
Top scorers (all competitions): Cristiano Ronaldo (Man Utd) 9; Riyad Mahrez (Man City) 8
Match odds: H 18-5 D 29-10 A 8-11
Referee: Michael Oliver
Brentford (12) v Norwich (20)
Bryan Mbeumo could start for Brentford following a hamstring issue. Kristoffer Ajer faces six weeks on the sidelines with a hamstring injury he sustained while on international duty with Norway, with Yoane Wissa and Shandon Baptiste also out through injury.
Norwich must do without captain Grant Hanley for several weeks with an adductor problem. Ozan Kabak is a doubt due to glandular fever, though Ben Gibson returns after suspension.
Last season: No corresponding fixture
Last five league matches: Brentford D W L L L; Norwich L D D L L
Top scorers (all competitions): Yoane Wissa and Marcus Forss (Brentford) 5; Josh Sargent (Norwich) 4
Match odds: H 4-7 D 29-10 A 8-11
Referee: Jarred Gillett
Chelsea (1) v Burnley (18) - Live on Premier Sports
Mason Mount could feature for Chelsea despite struggling with infected wisdom teeth. Marcos Alonso will miss out with an ankle problem, but Christian Pulisic and N’Golo Kante should be in action. Mateo Kovacic (thigh), Romelu Lukaku (ankle) and Timo Werner (thigh) are all still sidelined.
Burnley winger Aaron Lennon is a doubt due to illness. Otherwise, boss Sean Dyche looks set to have an unchanged group of players to choose from with Dale Stephens not yet ready to make his first-team return after injury.
Last season: Chelsea 2 Burnley 0, Burnley 0 Chelsea 3
Last five league matches: Chelsea L W W W W; Burnley D D L D W
Top scorers (all competitions): Romelu Lukaku and Reece James (Chelsea) 4; Jay Rodriguez, Chris Wood and Maxwel Cornet (Burnley) 4
Match odds: H 1-4 D 5-1 A 11-1
Referee: Andre Marriner
Crystal Palace (13) v Wolves (7)
Ebere Eze will again be absent for Crystal Palace despite stepping up his recovery from an Achilles injury. Defender Nathan Ferguson has also been out with the same issue but is set to take part in some modified first-team training next week.
Wolves remain without defender Fernando Marcal (calf) until after the international break. Full-back Jonny (knee), winger Pedro Neto (knee) and midfielder Yerson Mosquera (hamstring) are not expected to return until the new year.
Last season: Crystal Palace 1 Wolves 0, Wolves 2 Crystal Palace 0
Last five league matches: Crystal Palace D D D D W; Wolves W W W D W
Top scorers (all competitions): Odsonne Edouard (Crystal Palace) 6; Hwang Hee-chan (Wolves) 4
Match odds: H 6-4 D 11-5 A 2-1
Referee: Graham Scott
Brighton (8) v Newcastle (19), 5.30pm - Live on BT Sport
Brighton will check on the fitness of Dan Burn. The defender missed last weekend’s draw at Liverpool with a knee injury and it was thought he would not be available again until after the international break — but Albion boss Graham Potter thinks the 29-year-old is making good progress. Aaron Connolly (heel) should return but Danny Welbeck (hamstring) and Steven Alzate (ankle) remain out.
Defender Paul Dummett is Newcastle’s only absentee as he continues his recovery from a calf problem. Slovakia keeper Martin Dubravka was an unused substitute for last weekend’s defeat by Chelsea following his return from a foot injury and is now competing with Karl Darlow for a starting berth.
Last season: Brighton 3 Newcastle 0, Newcastle 0 Brighton 3
Last five league matches: Brighton D D D L D; Newcastle D L L D L
Top scorers (all competitions): Neal Maupay (Brighton) 4; Callum Wilson (Newcastle) 4
Match odds: H 8-13 D 29-10 A 24-5
Referee: David Coote
Sunday
Arsenal (6) v Watford (16), 2pm - Live on Sky Sports
Arsenal have Kieran Tierney back in contention after an ankle injury. Midfielder Granit Xhaka (knee) is a long-term absentee as manager Mikel Arteta considers naming the same starting XI for a third game in a row.
Watford will be without midfielder Ken Sema (MCL) and forward Kwadwo Baah (fractured ankle) after both sustained serious injuries in training this week. Francisco Sierralta and Kiko Femenia have returned to training after recent injuries while fellow defender Christian Kabasele has continued his recovery from a hamstring strain.
Last season: No corresponding fixture
Last five league matches: Arsenal W D D W W; Watford D L L W L
Top scorers (all competitions): Pierre-Emerick Aubameyang (Arsenal) 7; Ismaila Sarr (Watford) 4
Match odds: H 2-5 D 15-4 A 7-1
Referee: Kevin Friend
Everton (10) v Tottenham (9), 2pm
Everton midfielder Fabian Delph could make his first start of the season. Yerry Mina (thigh) remains out but fellow defender Lucas Digne, who missed the Wolves game, has trained this week and is expected to be available. Striker Dominic Calvert-Lewin (thigh) and midfielders Andre Gomes (calf) and Abdoulaye Doucoure (foot) are absent.
New Tottenham head coach Antonio Conte will assess his players after picking a full-strength side for their Thursday night Europa Conference League win against Vitesse Arnhem. Defender Ryan Sessegnon and midfielder Bryan Gil (both hamstring) are not expected to be fit.
Last season: Everton 2 Tottenham 2, Tottenham 0 Everton 1
Last five league matches: Everton W D L L L; Tottenham L W W L L
Top scorers (all competitions): Richarlison (Everton) 7; Harry Kane (Tottenham) 5
Match odds: H 2-1 D 23-10 A 7-5
Referee: Chris Kavanagh
Leeds (17) v Leicester (11), 2pm
Leeds are assessing Jamie Shackleton, who was forced off with a knock during the win at Norwich last weekend, and Junior Firpo who has been out for over a month with a muscle injury. The Whites are already without Luke Ayling (knee), Robin Koch (pelvis) and Patrick Bamford (ankle).
James Maddison and Harvey Barnes are expected to be available for Leicester after illness. James Justin is close to a return after a serious knee injury but Wesley Fofana (broken leg) is out and Marc Albrighton is not expected back until the end of the month.
Last season: Leicester 1 Leeds 3, Leeds 1 Leicester 4
Last five league matches: Leeds L W L D W; Leicester D D W W L
Top scorers (all competitions): Raphinha (Leeds) 4; Jamie Vardy (Leicester) 7
Match odds: H 17-10 D 13-5 A 6-4
Referee: Darren England
West Ham (4) v Liverpool (2), 4.30pm - Live on Sky Sports
Nikola Vlasic and Andriy Yarmolenko will rejoin the West Ham squad after minor injury concerns. Lukasz Fabianski will resume in goal while Angelo Ogbonna, Kurt Zouma, Tomas Soucek, Said Benrahma, Jarrod Bowen and Pablo Fornals could also return after sitting out the Europa League draw with Genk.
Liverpool forward Roberto Firmino has been ruled out for at least a month with a hamstring injury. Midfielders Naby Keita and James Milner (both hamstring) and Curtis Jones (eye) and centre-back Joe Gomez (calf) are also sidelined. Midfielder Fabinho (knee) will start his first Premier League match in a month.
Last season: West Ham 1 Liverpool 3, Liverpool 2 West Ham 1
Last five league matches: West Ham W L W W W; Liverpool D D W W D
Top scorers (all competitions): Michail Antonio (West Ham) 7; Mohamed Salah (Liverpool) 15
Match odds: H 18-5 D 29-10 A 8-11
Referee: Craig Pawson
