Liverpool 1 Lyon 2:Liverpool's season fell further into disarray at Anfield this evening after two Lyon substitutes hit the net to overhaul Yossi Benayoun's opener and consign their hosts to a fourth defeat in a row - a run that represents Liverpool's worst form since 1987.
The defeat will be compounded by the fact that captain Steven Gerrard limped off in the first half, while the absent Fernando Torres remains a worry ahead of the league clash with Manchester United this Sunday.
Benayoun gave the Merseysiders the lead at the end of a scrappy first half when Fabio Aurelio’s cross beat everyone but the Israeli, who calmly slotted home for the lead.
However, the homeside invited their opponents on in the second period and were punished by Maxime Gonalons in the 72nd minute and Cesar Delgado in the 91st.
Gonalons headed home after two quickfire saves from Pepe Reina weren't enough to clear the danger from a Lyon corner.
Emiliano Insua was then exposed on the break for the winner as Delgado popped up at the backpost to slot home.
Liverpool are now fourth in Group E, with three points from three games, and trail leaders Lyon by six and Fiorentina, who beat Debrecen4-3 in Hungary, by three.
“It’s a massive disappointment, a bad result which leaves us a lot to do," vice captain Jamie Carragher told Sky Sports 2 afterwards.
“We’re going through a tough patch but we’ve been through them before, we will come through no doubt.
“We have great fight and character. We had a lot of young lads out there tonight, if we could have hung on (for a draw) it would have been a good result.”
Despite their poor run, Carragher feels facing Barclays Premier League leaders United at Anfield could be the ideal fixture.
“It’s always a great game, they are a top side,” he added. “That could be the game we need.”
Arsenalsaw their 100 per cent record in Group H ended as David Mendes Da Silva volleyed an injury-time equaliser for AZ Alkmaarto cancel out Cesc Fabregas' opener and earn a 1-1 draw for Ronald Koeman's men.
Ieroklis Stoltidis headed an injury-time winner for Olympiacosas they came from behind to beat Standard Liege2-1 and strengthen their position in second behind the Gunners.
Igor De Camargo scored first for the Belgian side before Kostas Mitroglou levelled two minutes before the break.
Rubin Kazansilenced the Nou Camp just two minutes into their Champions League clash with Barcelona as the holders slipped to a shock 2-1 defeat.
Alexander Ryazantsev's 35-yard rocket gave the Russians the lead in the Group F encounter - and left Barcatrailing for the first time this season.
Zlatan Ibrahimovic levelled in the 48th minute, controlling the ball on his chest and firing home via a post, but there was another twist to come as Gokdeniz Karadeniz grabbed a 73rd-minute winner.
Another upset looked on the cards at the San Siro as Dynamo Kievtwice led against Inter Milanonly for Jose Mourinho's men to fight back to draw 2-2.
Taras Mykhalyk put Dynamo Kiev in front after five minutes and Lucio powered a header into his own net to restore their lead after Dejan Stankovic had levelled.
But Walter Samuel headed in at the right end two minutes after the break to make it 2-2.
Sevillawon 3-1 at Stuttgartto extend their perfect record in Group G and strengthen their position at its summit.
Sebastien Squillaci scored twice either side of a Jesus Navas goal as the visitors took command of the match before Elson scored a consolation for Markus Babbel’s men.
Two own goals and a missed penalty sent Rangerson their way to a 4-1 home defeat to Romanian side Unirea Urziceni, who now lie second, five points behind Sevilla.
Fortune looked like it would favour the Scottish side when Ricardo Vilana deflected Pedro Mendes’s shot into his own net to give them a second-minute lead.
But from there it went downhill for the home side, Marius Bilasco equalising in the 33rd minute and Steven Davis missing a penalty five minutes later.
Own goals from Kyle Lafferty and Lee McCulloch put Unirea in control, Pablo Brandan adding their fourth in the 65th minute.