Aston Villa (11) v Sheff Utd (15)Villa are without forward Shaun Maloney (ankle), with manager Martin O'Neill expected to retain the starting line-up who won away to Manchester City last weekend. Blades boss Neil Warnock has almost a full squad to choose from. Striker Rob Hulse remains the only long-term casualty after sustaining a broken leg earlier in the season.
Everton (6) v Portsmouth (8)
Goalkeeper Tim Howard is set to replace Iain Turner, having been ineligible for last weekend's defeat against former club Manchester United. Striker Andrew Johnson (ankle) is not expected to be involved while Victor Anichebe (ankle) is close to a return.
Pedro Mendes returns for Pompey after ankle surgery. Sol Campbell (Achilles) could still play despite being ruled out for the season earlier this week, while Dejan Stefanovic (thigh), Matt Taylor (ankle) and Richard Hughes (knee) are major doubts. Striker Svetoslav Todorov is available again after a knee injury.
Fulham (16) v Liverpool (3)
Cottagers defenders Franck Queudrue (ankle) and Ian Pearce (calf) remain in the treatment room and will be unavailable, as are midfielders Jimmy Bullard (knee), Mark Pembridge (calf) and Simon Elliott (calf).
Liverpool captain Steven Gerrard is almost certain to join John Arne Riise, Steve Finnan, Jamie Carragher and Jose Reina in being rested. Italian Under-21 goalkeeper Daniele Padelli could make his debut, with teenage Argentinian full-back Emiliano Insua — who made his debut at Portsmouth — getting another outing.
Man City (13) v Man Utd (1)
Michael Johnson is set to replace Joey Barton in City's midfield. Barton has been suspended for the remainder of the season following the training ground assault on Ousmane Dabo which has ensured the Frenchman will also miss out on the derby game.
Centre-back Rio Ferdinand seems certain to start for United, as do forwards Louis Saha and Alan Smith. Left-back Patrice Evra is available after suspension and could replace Gabriel Heinze.
Newcastle (12) v Blackburn (10)
Scott Parker and Nicky Butt are back in training after ankle problems, and are needed with Emre (ankle), Antoine Sibierski (broken arm) and Damien Duff (ankle), out for the rest of the season. Michael Owen (knee) and Shola Ameobi (hip) have had no reaction to their return to action at Reading, but the game comes too soon for goalkeeper Shay Given (groin).
Rovers midfielder David Dunn is ruled out with the thigh injury which forced him off during last week's win over Charlton. Boss Mark Hughes is also without defender Zurab Khizanishvili, who has a knee injury which club doctors believe may require surgery this summer.
Reading (7) v Watford (20)
Reading welcome back striker Leroy Lita after a three-match ban. Midfielder Steve Sidwell also returns after he was left out of Monday's home win over Newcastle. Defender Graeme Murty (calf) and winger Glen Little (Achilles) are sidelined, as are long-term victims Ibrahima Sonko and Bobby Convey (both knee).
Watford boss Adrian Boothroyd must reshuffle his defence, after centre-back Clarke Carlisle was handed a one-match ban. With Jay DeMerit rested, Boothroyd must decide whether to partner Danny Shittu with Adrian Mariappa, Lloyd Doyley or Cedric Avinel. Full-back Jordan Stewart must come through a fitness test but Gavin Mahon is rated as only a 50/50 chance.
West Ham (18) v Bolton (5)
Hammers defenders Matthew Upson (calf) and Danny Gabbidon (groin) are out for the season. Marlon Harewood and Bobby Zamora vie for a place in attack, while Dean Ashton (ankle) remains a long-term absentee.
Bolton captain Kevin Nolan may return after an ankle injury. Stelios Giannakopoulos (groin) and Abdoulaye Faye (toe) face fitness tests but Tal Ben Haim, El-Hadji Diouf and Nicky Hunt are again ruled out.
Wigan (17) v Middlesbrough (14)
Winger Antonio Valencia returns to the squad after serving a three-match ban. Wigan will have to make another defensive change with skipper Arjan de Zeeuw sustaining an ankle injury against West Ham.
Boro defender Abel Xavier is unlikely to make the squad because of a knee injury. Midfielder Julio Arca returned from a groin strain as a substitute against Tottenham last week and is in contention for a start, while full-back Andrew Taylor is likely to play his last game before undergoing surgery on his big toe.
Sunday
Arsenal (4) v Chelsea (2)
Arsenal midfielder Tomas Rosicky is rated as only 50-50 because of a hamstring problem. Freddie Ljungberg (hamstring) has already been ruled out. Captain Thierry Henry (groin and stomach), Robin van Persie (broken foot) and Theo Walcott (shoulder) are all sidelined.
Chelsea have fitness doubts over Ricardo Carvalho (knee) and Andriy Shevchenko (groin). Michael Ballack has undergone ankle ligament surgery and is not expected to return this season.
Monday
Charlton (19) v Tottenham (9)
Charlton will be without suspended full-back Ben Thatcher while Hermann Hreidarsson (knee) is a slight concern. Souleymane Diawara or Madjid Bougherra are available as cover in the centre of defence. On-loan keeper Scott Carson makes his last appearance as he is ineligible for next weekend's trip to Liverpool.
Spurs hope Robbie Keane recovers from an ankle injury, while defenders Benoit Assou-Ekotto (knee) and Anthony Gardner (fractured leg) have been back in training. Teemu Tainio is available after ankle trouble but Mido (groin), Paul Stalteri (knee) and Lee Young-Pyo (knee) miss out.
