Manchester United keeper Edwin Van Der Sar has been ruled out of Tuesday's Champions League clash with Roma at Old Trafford with a toe injury.

The Dutchman suffered the setback during the first half of United's 1-0 win over Birmingham at St Andrews which lifted them back into second place in the Barclays Premier League.

Van Der Sar continued between the posts until half-time, but was then replaced for the second 45 minutes by Tomasz Kuszczak.

His injury took the shine off a fortuitous single-goal victory courtesy of Cristiano Ronaldo's 51st-minute strike.

United boss Sir Alex Ferguson said: "Van Der Sar has damaged his toe. To what extent, we are not sure. We will send him for a scan but he will definitely be out on Tuesday.

"It is a worry to lose a man of his experience, but Tomasz is very able and we are pleased we've got someone as good as him."

Owen Hargreaves has warned United's expectant fans to forget any chance of a repeat of their magnificent seven-goal salvo against Roma this week.

The Serie A giant suffered one of the biggest humiliations of their entire history at the hands of United last year.

Protecting a single-goal advantage from the first leg of their quarter-final, Roma were ravaged by one of the finest performances of Sir Alex Ferguson's entire 20-year reign.

But Hargreaves, who his set to make his European bow for United after finally recovering from the thigh strain he suffered on international duty with England, is looking only for a repeat of the result rather than the scoreline.

"There will be no repeat of the 7-1," he said. "Those results possibly happen once every three or four years in the entire competition. It is just not going to happen again.

"As long as we get the three points, I will be happy."