Fraance v Ukraine: With both teams level with Scotland on 12 points at the head of Group B, a win for either would put them top while the inactive Scots watch from the sidelines.
France have managed to score only one goal in three meetings with Ukraine, a last-gap Zinedine Zidane winner giving them a 1-0 victory in a Euro 2004 warm-up.
David Trezeguet has been overlooked by coach Raymond Domenech, who is relying on Nicolas Anelka and Djibril Cisse for goals with uncapped Jimmy Briand an option from the bench. Captain Patrick Vieira is also out through injury as well as right back Willy Sagnol.
Andriy Shevchenko is missing for Ukraine after undergoing hernia surgery this month. Also missing are Serhiy Rebrov and Artem Milevsky.
Faroe Islands v Italy: AC Milan defender Alessandro Nesta has opted to get married instead of joining the Italy squad while striker Alberto Gilardino decided to have a knee operation rather than wait until after the Group B double header, which includes Wednesday's trip to Lithuania.
Francesco Totti, Serie A's top scorer this season with 26 goals, is continuing his international sabbatical. Luca Toni's foot operation rules him out, while Udinese striker Vicenzo Iaquinta is missing with a toe problem and Juventus winger Mauro Camoranesi is also injured.
Barcelona left-back Gianluca Zambrotta is also out for the first match with a knee problem while Massimo Ambrosini is struggling with a calf strain.
Defender Frodi Benjaminsen is suspended for the islanders.
Belgium v Portugal: With new team-mate Cristiano Ronaldo suspended, Manchester United's new signing Nani has become even more central to coach Felipe Scolari's plans in Brussels tonight.
"Nani is essential to our success, even more so now," Scolari said.
Portugal lie second in Group A on 11 points from six matches, level with Serbia and Finland, but five points behind leaders Poland who have played one match more. Belgium have seven points from six outings.
"We must win as we are behind our plan and anything less than three points will make things difficult for us," Scolari added.
Spain v Latvia: Uncapped Osasuna striker Roberto Soldado is likely to start for Spain today's Group F qualifier against Latvia.
With Fernando Torres injured, Soldado, who has scored 11 league goals since joining on loan from Real Madrid at the start of the season, is likely to partner the live-wire David Villa up front in Riga.
Back-to-back defeats by Northern Ireland and Sweden threatened to derail Spain's campaign, but wins over Denmark and Iceland mean qualification is back in their hands.
Coach Luis Aragones's only other doubt is on the left side of midfield. The in-form David Silva has muscle problems and Barcelona's Andres Iniesta could take his place.
Latvian midfielder Imants Bleidelis will win his 100th cap if he plays.